くすりのしおり

External
Published: 5/2016

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Marduox Ointment
 Active ingredient:
Maxacalcitol
Betamethasone butyrate propionate
 Dosage form:
white translucent ointment
 Print on wrapping:
マーデュオックス軟膏

Effects of this medicine

This medicine is a combination ointment containing active vitamin D3 derivative (maxacalcitol) and steroid (betamethasone butyrate propionate). Active vitamin D3 derivatives suppress the proliferation of epidermal keratinocytes and improve acanthosis. Steroids suppress skin inflammation and improve symptoms such as redness, swelling and itch.
It is usually used to treat psoriasis vulgaris.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have skin infections due to bacteria or fungi, ulcer, burn/frostbite, hypercalcemia or a risk of hypercalcemia, or decreased renal function.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, apply an appropriate amount of the medicine to the affected area, once a day. Strictly follow the instructions.
  • The daily dose is up to 10 g (when using concomitantly with ointments including maxacalcitol, the total dose is up to 10 g (250 mcg as maxacalcitol). Wash your hands thoroughly after applying the ointment.
  • Do not apply the ointment to normal skin. Pay attention not to get the medicine in the eye. Do not touch a wound with the hand that applied the ointment.
  • If you miss a dose, apply the missed dose when you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never apply two doses at one time.
  • If you accidentally apply more than your prescribed dose or accidentally ingest this medicine, consult with your doctor or pharmacist.
  • Do not stop applying this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • Laboratory tests, including blood calcium level measurements, and renal function tests will be performed regularly to check for adverse reactions that you may not notice yourself. Consult with your doctor as directed by your doctor.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include folliculitis, skin irritation, rash and abnormal liver function. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • dry mouth, malaise, lassitude [hypercalcemia]
  • decreased urine output, edema, general malaise [acute renal failure]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
  • Discard the remainder. Do not store them. Ask your pharmacy or medical institution on how to discard the remainder.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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