くすりのしおり

Injection
Published: 3/2016

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
YERVOY Injection 50mg
 Active ingredient:
Ipilimumab(genetical recombination)
 Dosage form:
injection
 Print on wrapping:

Effects of this medicine

This medicine is human anti-CTLA-4 (cytotoxic T-lymphocyte-associated antigen 4) monoclonal antibody. It binds to CTLA-4 receptor of T-cell (immune cell) to enhance growth/activation/cytotoxic activity of tumor antigen-specific T-cell. It consequently suppresses tumor growth. It also decreases regulatory T-cell (Treg) function and reduces the number of Treg in the tumor tissue. It consequently increases anti-tumor immune response and suppresses tumor growth.
It is usually used to treat radically unresectable malignant melanoma.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
    If you have liver dysfunction.
    If you have complication of autoimmune disease or have a history of chronic/recurrent autoimmune disease.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • In general, for adults, inject intravenously once a day at an interval of once every 3 weeks for a total of 4 doses.

Precautions while taking this medicine

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include rash, fever, itching, decreased appetite and diarrhea. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, see your doctor immediately.
  • diarrhea, abdominal pain, bloody stool [colitis, perforation of the digestive tract, severe diarrhea]
  • general malaise, loss of appetite, jaundice [liver failure, liver dysfunction]
  • rash, skin itching, pain [severe skin disorder]
  • headache, general malaise, defect in the visual field [hypophysitis, hypopituitarism, hypothyroidism, adrenal gland dysfunction]
  • chill, dizziness, respiratory distress [infusion reation]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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