くすりのしおり

Internal
Revised: 3/2015

The information on this sheet is based on approvals granted by the Japanese regulatory authority. Approval details may vary by country. Medicines have adverse reactions (risks) as well as efficacies (benefits). It is important to minimize adverse reactions and maximize efficacy. To obtain a better therapeutic response, patients should understand their medication and cooperate with the treatment.
Brand name :
Certican Tablets 0.5mg
 Active ingredient:
Everolimus
 Dosage form:
white to yellow tablet, φ: 7.0 mm, thickness: 2.8 mm
 Print on wrapping:
CERTICAN, サーティカン錠0.5mg (letter color: blue)

Effects of this medicine

This medicine inhibits growth of T cell which relates immunity to suppress abnormal immune reactions.
It is usually used for inhibition of the rejection response to transplanted heart or kidney.

Before using this medicine, be sure to tell your doctor and pharmacist

  • If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
  • If you are pregnant or breastfeeding.
  • If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Dosing schedule (How to take this medicine)

  • Your dosing schedule prescribed by your doctor is ((        to be written by a healthcare professional))
  • For heart transplantation: In general, for adults, take 0.75 mg of the active ingredient at a time, twice a day. As initial dose, it may be 3 tablets (1.5 mg) at a time, twice a day.
    For kidney transplantation: In general, for adults, take 0.75 mg of the active ingredient at a time, twice a day.
    In any case, the dosage should be adjusted according to the age, symptoms or blood level of the medicine. Strictly follow the instructions.
    This preparation contains 0.5 mg of the active ingredient in a tablet, and may be used in combination with tablets of different content amount.
  • If you miss a dose, take a dose as soon as possible. Take the next dose at least 5 hours apart. You should never take two doses at one time.
  • If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
  • Do not stop taking this medicine unless your doctor instructs you to do so.

Precautions while taking this medicine

  • While taking the medicine, your natural immunity will be reduced. To prevent infections, often wash your hands, gargle, and brush your teeth.
  • Consult with your doctor when you receive a vaccination.
  • Grapefruit juice may intensify the effect of the medicine by increasing its blood level. Health foods containing St. Jone's wart may reduce the effect of the medicine by decreasing its blood level. Avoid taking these foods and drinks.

Possible adverse reactions to this medicine

The most commonly reported adverse reactions include hyperlipidemia, hypercholesterolemia, nasopharyngitis, fever and hypertension. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  • enlargement of lymph nodes, fever, loss of appetite [malignant lymphoma, lymphoproliferative disease, malignant tumor (especially of the skin)]
  • decrease of urine output, swelling, fatigability [renal disorder]
  • fever, breathlessness, rash [infection]
  • bleeding tendency, fatigability, swelling [hemolytic uremic syndrome, thrombotic thrombocytopenic purpura-like symptoms]
  • fever, dry cough, general malaise [interstitial pneumonia, pneumonitis]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.

Storage conditions and other information

  • Keep out the reach of children. Store away from direct sunlight, heat and moisture.
  • Keep in press-through package (PTP) sheet just before taking to avoid light and moisture.
  • Discard the remainder. Do not store them. Ask the pharmacy or medical institution how to discard.

For healthcare professional use only : Day Month Year

For further information, talk to your doctor or pharmacist.

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